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KMID : 0620920130450090003
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Experimental & Molecular Medicine
2013 Volume.45 No. 9 p.3 ~ p.0
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The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis
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Kim Sang-Doo
Kwon Soon-Il
Lee Sung-Kyun
Kook Min-Soo
Lee Ha-Young
Song Ki-Duk
Lee Hak-Kyo
Baek Suk-Hwan
Park Chan-Bae
Bae Yoe-Sik
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Abstract
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In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW, indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-β production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.
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KEYWORD
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therapeutics, ulcerative colitis, WKYMVm
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